The Shelter is intended for the automated determination of cognitive functions (learnability and memory) of laboratory animals on the basis of the response of avoiding of an electrocutaneous irritant. It allows testing for mice or rats.
The following parameters are determined as a result of testing:
The software package of "Shelter" was primarily designed for experiments on the following methods:
1 The conditional reaction of passive avoidance (CRPA)
The enclosed space where the rodent is placed is divided into two chambers, in one of them there is light, in the other is darkness.
The rodent is placed in the bright compartment. As soon as the rodent goes to the dark side – the electric grid and sharp sound turn on.
The rodent is placed on a small platform located at a certain height from the floor.
As soon as the rodent goes down, electrocutaneous irritation begins.
2The conditional reaction of active avoidance (CRAA)
The room is divided into two compartments. The rodent is presented with a sequence of stimuli (light, pause, electric current with a sharp sound).
The rodent has to study to be in time to move from one compartment to another before the emergence of electroskin irritation.
3 Conflict situations by Vogel
The rodent is not given food or water for a long time.
The rodent is placed in the compartment, where there is a feeder or a drinking bowl.
As soon as the rodent comes to the water or food in the compartment starts electrocutaneous stimulation.
4Preference of place
For this technique, walls with different wallpaper (squares, strips, dots) are used.
The preferred wallpaper is determined according to measures the residence time of the rodent in different rooms.
|Linear dimensions (WxHxD)||600х520х320 mm|
|Materials||opaque black plexiglass, aluminum, steel|
|Detection of staying on the platform||Optical in the infrared range|
|Connecting to a computer||USB|
|Platform illumination at a daylight with the closed doors, without internal lamps||2 lx|
|Platform illumination by the light of lamps on the one side||115 lx|
|Platform illumination by the light of lamps from the both sides||185 lx|
|Step of an electric grid
the distance between the axes of rods
|Grid for rats: 16 mm
Grid for mice: 8 mm
|The free distance between the rods||Grid for rats: 13 мм
Grid for mice: 5 мм
|The diameter of the rods of the electric grid||3 мм|
|Pulsing||automatic (controled by software)|
|Polarity switching on rods||10 Hz, 8 phases|
|Minimum duration of an electric pulse||50 ms|
|Maximum current strength of the electric grid||15 mA|
|Maximum voltage of the electric grid||100 V|
|Power supply||220 V|
|PC requirements||Processor not less then Сore 2 Duo
Microsoft Windows 7 SP1/8/10
(it is necessary to have Microsoft .NET Framework 4.5)
|Production||Russia, LLC «Neurobotics»|
The hardware-software complex is created according to safety requirements of the medical equipment:
The electric grid is the floor in the Shelter. The walls can be easily removed, washed, replaced by other.
Types of walls:
|Motorized door with a hole resembling burrow||On request|
|The set of wallpapers
6 options, each option contains 4 walls, total in the set - 24 walls
|Electro grid for the rats||On request|