Equipment for animal physiology research
Moscow, Zelenograd

Systole: non-invasive blood pressure measurement for rodents

Systola - System of noninvasive measurement of blood pressure (NIBP non-invasive blood pressure) of rats and mice

"Systole" is intended for non-invasive measurement of systolic and diastolic pressure from the tail of rodents of small and medium sizes: rats and mice.

The built-in pomp automatically forces pressure in a tail-cuff until the termination of pulsations of a bloodstream, then, slowly reducing pressure, measures systolic and diastolic pressure on a basis of indications of the infrared sensor of the pulse which is put on a tail of an animal after a cuff.

ATTENTION! It is obligatory to heat the animal for noninvasive measurement of blood pressure in rats and mice. It allows to provide blood circulation in the tail in the necessary volume and to stabilize a bloodstream. It is obligatory to preheat the animal to a temperature of 28-32 C° for 10-15 minutes. Such mode of heating has to be supported during all procedure of measurement of pressure. For heating it is offered to use the heating platform Phlogiston or other suitable system of heating of small animals.


Max pressure in the cuff up to 300 mmHg
Pressure measurement error up to 3 mmHg (1% of range)
Types of cuffs • ∅5-10 mm tail (rats)
• ∅3-6 mm tail (mice)
Pulse sensor (PPG) infrared
Pulse rate 40-600 bpm
Measuring cycle time 30-50 s (depends on the pressure measuring range)
Emergency stop Software and hardware
Data recording frequency 1000 Hz
Connection interface USB 2.0
Power supply via USB (5V, 400 mA)
Dimensions 190х100х40 mm
Weight 350 g
Supported OS • Windows 10+
• Ubuntu 22+
Warranty 1 year
Production Russia, LLC «Neurobotics»

Specifications and prices

Standard Systole package
  • single channel non-invasive blood pressure measurement system
  • cuff (optional for rats or for mice)
  • infrared PPG sensor
  • rodent restrainer Teremoque (size by choice),
  • spare cuff membranes (4 pcs.)
On request
Heating platform Phlogiston On request
Cuff 5-10 mm (for rats) On request
Cuff 3-6 mm (for mice) On request


Systole software (v2.0.0)

Systole manual (v2.0.0)

Systole software changelog

Systole: NIBP measurement
NIBP measurement
Systole: record view
Systole: summarized experiment table
Multiexperiment summary

Resources and Downloads

Document that the Systole isn't listed in the Federal Registration Service of measuring instruments

General questions

How long does it take to warm up a rat?
How do you know if a rat is warm enough to take a measurement?
We got a strange result when measuring. With what it can be connected?
How often does Systole device need to be verified?

Systola is not in the list of measuring means (according to the Russian Gosreestr) and doesn't need to verified.

The calibration procedure can be found in the manual.